| production method | the preparation method is the reaction of p-chlorobenzaldehyde with methylamine and acetic anhydride to obtain 2-chlorophenylsarcosine. An aqueous solution of 9.0g(0.13mol) of methylamine hydrochloride and an aqueous solution of 5.3g(0.10mol) of sodium cyanide were added to a solution of 14.4g(0.10mol) of p-chlorobenzaldehyde in tetrahydrofuran and stirred at room temperature for 16.0h, it was extracted with toluene, and then 1.0mL of pyridine and 5.0mL of acetic anhydride were added. The reaction was stirred at room temperature for 60.0H and then concentrated in vacuo to obtain an oily liquid. The oil was added to a 1: 1 water/concentrated hydrochloric acid mixture, heated to reflux for 2.0h, cooled, diluted with water, neutralized to pH = 2 with 50%NaOH solution, A solid precipitate was precipitated, filtered and dried to obtain 17.3g of 2-p-chlorophenylsarcosine in a yield of 82.4. |
